Nanoparticles for drug delivery

A delivery system for the anti-tumorigenic cytokine IFN-g have been developed based on dimercaptosuccinic acid (DMSA)-coated monodisperse magnetic nanoparticles. IFN-g-adsorbed DMSA coated magnetic nanoparticles were targeted to the tumor site by application of an external magnetic field. We analyzed nanoparticle biodistribution before and after IFN-g conjugation, as well as the efficiency of nanoparticle accumulation in tumors, IFN-g release in the area of interest, and the effects of both on tumor development. At the tumor site, we observed a high degree of nanoparticle accumulation and of cytokine delivery, which led to increased T cell and macrophage infiltration and promoted an antiangiogenic effect. The combined action led to a notable reduction in tumor size. Our findings indicate that IFN-g-adsorbed DMSA-coated magnetite nanoparticles can be used as an efficient in vivo drug delivery system for tumor immunotherapy

Instituto de Ciencia de Materiales de Madrid, CSIC