{"id":1902,"date":"2025-11-05T10:06:24","date_gmt":"2025-11-05T10:06:24","guid":{"rendered":"https:\/\/wp.icmm.csic.es\/csc\/?page_id=1902"},"modified":"2025-11-05T10:09:07","modified_gmt":"2025-11-05T10:09:07","slug":"hymanare","status":"publish","type":"page","link":"https:\/\/wp.icmm.csic.es\/csc\/hymanare\/","title":{"rendered":"HyMaNaRe"},"content":{"rendered":"

HyMaNaRe (PID2023-150170OB-I00; PI: Mar\u00eda Concepci\u00f3n Serrano; 250 k\u20ac)<\/strong><\/p>\n

This page is specifically devoted to the content and advances related to the development of the research project HyMaNaRe, a Reseach Project funded by the Agencia Espa\u00f1ola de Investigaci\u00f3n<\/em> from the Ministerio de Ciencia, Innovaci\u00f3n y Universidades<\/em> of Spain. Since September 1st, 2024 through August 31st 2027, we will devote effort to the development of novel regenerative medicine strategies applied to SCI and stands on three major interdisciplinary pillars: nanotechnology, neural repair and motor rehabilitation (Scheme<\/strong>). To accomplish this overall aim, the general objectives are:<\/p>\n

    \n
  1. Production of soft and silica-reinforced hybrid bio-implants<\/u> based on hydrogels containing magnetic nanoparticles.<\/li>\n
  2. Controlled release of neuroactive cargos by means of magnetic fields<\/u> according to the temporal evolution of SCI damage and repair.<\/li>\n
  3. Examination of the degradation, biocompatibility and neuroregenerative capacity<\/u> of the resulting bio-implants in-vitro <\/em>(neural and non-neural cell cultures) and in-vivo <\/em>(cervical C6 hemisection model of SCI in rats).<\/li>\n<\/ol>\n

    \"\"<\/p>\n

    This scheme depicts the main work hypothesis for the project, including the design of therapeutic magnetic bio-implants for neural repair (modified from doi.org\/10.1038\/s41563-023-01760-5<\/a>; doi.org\/10.1038\/s41467-023-44481-8<\/a>; doi.org\/10.3390\/ijms232213833<\/a>).<\/p>\n

    The specific objectives are:<\/p>\n

    OBJECTIVE 1.<\/em><\/strong> Design and development of novel theranostic regenerative implants for neural repair based on silica-reinforced natural hydrogels containing chitosan-coated IONPs with neurotherapeutic cargos.<\/p>\n

    OBJECTIVE<\/em><\/strong> 2<\/em>.<\/strong>  Optimization of the implant lifetime: Biodegradation studies including temporal evolution of the physicochemical parameters of the implants and their fabrication by bioprinting.<\/p>\n

    OBJECTIVE 3. <\/em><\/strong>Evaluation of the biocompatibility in vitro <\/em>of the nanomedicines developed, with particular focus on oxidative stress responses including ferroptosis.<\/p>\n

    OBJECTIVE 4<\/em><\/strong>.<\/em> Analysis of the effect of magnetic fields, static (constant and gradients) and dynamic, on neural cells (in-vitro<\/em>) and tissues (in-vivo<\/em>) and the impact of magnetic nanoparticles on the biological responses found.<\/em><\/strong><\/p>\n

    OBJECTIVE 5. <\/em><\/strong>Study of the diagnostic and regenerative capability in vivo <\/em>of the resulting magnetic bio-implants in combination with magnetic fields and motor training routines in experimental models of SCI in rats.<\/p>\n","protected":false},"excerpt":{"rendered":"

    HyMaNaRe (PID2023-150170OB-I00; PI: Mar\u00eda Concepci\u00f3n Serrano; 250 k\u20ac) This page is specifically devoted to the content and advances related to the development of the research project HyMaNaRe, a Reseach Project funded by the Agencia Espa\u00f1ola de Investigaci\u00f3n from the Ministerio de Ciencia, Innovaci\u00f3n y Universidades of Spain. Since September 1st, 2024 through August 31st 2027,…
    Leer m\u00e1s<\/a><\/p>\n","protected":false},"author":78,"featured_media":0,"parent":0,"menu_order":1,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-1902","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/pages\/1902","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/users\/78"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/comments?post=1902"}],"version-history":[{"count":2,"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/pages\/1902\/revisions"}],"predecessor-version":[{"id":1907,"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/pages\/1902\/revisions\/1907"}],"wp:attachment":[{"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/media?parent=1902"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}