{"id":35,"date":"2011-12-12T15:21:04","date_gmt":"2011-12-12T14:21:04","guid":{"rendered":"http:\/\/www.icmm.csic.es\/csc\/?page_id=35"},"modified":"2025-09-16T10:39:26","modified_gmt":"2025-09-16T10:39:26","slug":"projects","status":"publish","type":"page","link":"https:\/\/wp.icmm.csic.es\/csc\/projects\/","title":{"rendered":"Projects"},"content":{"rendered":"

In the last 10 years, the permanent members of the MAMBIO Group have participated as coordinators\/WP leaders\/principal investigators in over 25 different research projects funded by the European Commission (8; e.g., <\/em>Piezo4Spine, HyPELignum, MULTIFUN, NANOMAG and ByAxon), the Spanish Government (8; e.g., <\/em>TED2021-130191B-C41, IRONM@N, MAGO, COMANCHE and MAG4SPINAL), the Comunidad de Madrid Regional Funding Programmes (2) and others (7), with a total budget of over 8.5 M\u20ac. Further details on the most relevant past and present projects are included below (current ones are in bold):<\/p>\n

Nanomedicinas teranosticas basadas en hidrogeles y nanoparticulas magneticas con capacidad para regeneracion neural<\/u>, IP: Mar\u00eda Concepci\u00f3n Serrano L\u00f3pez-Terradas, Proyectos de Generaci\u00f3n de Conocimiento 2023. PID2023-150170OB-I00, 200.000\u20ac, Sep 2024-2027.<\/h4>\n

H2umidity\u00ae-PLUS<\/span>: Desarrollo de electrolizador mediante desarrollo de nuevos materiales y la tecnolog\u00eda \u00abH2umidity\u00bb que permite aprovechar la humedad del ambiente logrando una generaci\u00f3n de H2 verde en cualquier lugar
\nFunding agency: Programa 4 H2 Cadena de Valor, Uni\u00f3n Europea\u2013NextGenerationEU, Ministerio para la Transici\u00f3n Ecol\u00f3gica y el Reto Demogr\u00e1fico (IDEA, Spain)<\/strong>
\nPrincipal investigator: M. Puerto Morales (ICMM) and Natalia Rey Raap (INCAR)<\/strong>
\nTotal amount: 1.9 M\u20ac; 524 k\u20ac CSIC;  200 k\u20ac MaMBIO. Period: 36 months (2024-2027)<\/strong><\/h4>\n

Advanced Strategies and new Approaches for Protontherapy (ASAP-CM) (Ref. S2022\/BMD-7434)<\/span>:
\nFunding agency: Comunidad de Madrid (Ayudas a programas de actividades de I+D Biomedicina 2022)
\nPrincipal investigator: Luis Mario Fraile (UCM); Puerto Morales and Ana Espinosa (CSIC)
\nTotal amount: 47 k\u20ac. Period: 4 years (2023-2026)<\/strong><\/h4>\n

Piezo4Spine: Piezo-driven theramesh: A revolutionary multifaceted actuator to repair the injured spinal cord (GA 101098597)<\/span>:<\/strong>
\nFunding agency: HORIZON-EIC-2022-PATHFINDEROPEN-01
\nCoordinator: M. Concepci\u00f3n Serrano (ICMM-CSIC)
\nICMM Participants: MaMBIO and ForceTool Groups
\nParticipants: ICMM-CSIC, HNP-SESCAM (Spain), IIT (Italy), UC (Portugal), UCLouvain (Belgium), Black-Drop (Germany), and ACIB (Austria)
\nTotal amount: 3.5 M\u20ac; 1 M\u20ac for ICMM-CSIC. Period: 4 years (starting from 01\/2023)
\nFor further details, please visit the project website at https:\/\/piezo4spine.eu<\/a><\/h4>\n

Renewable energy to chemical mediated by H2O splitting coupling with CO2 capture and conversion (TED2021-130191B-C41)<\/span>:<\/strong>
\nFunding agency: MICINN (AEI, Proyectos orientados a la transici\u00f3n ecol\u00f3gica y a la transici\u00f3n digital)
\nCoordinator: Pascual O\u00f1a Burgos (ITQ-CSIC)
\nPrincipal investigator Subproject 3: M. Puerto Morales
\nParticipants: ITQ, US, ICMM and UCA
\nTotal amount: 263 k\u20ac for MaMBIO. Period: 01\/12\/2022-30\/09\/2025<\/h4>\n

HyPELignum: Exploring wooden materials in hybrid printed electronics: a holistic approach towards functional electronics with net zero carbon emissions (Project ID: 101070302)<\/span>:<\/strong>
\nFunding agency: HORIZON-CL4-2021-DIGITAL-EMERGING-01, Programme: Functional electronics for green and circular economy (RIA)
\nPrincipal investigator: M. Puerto Morales
\nTotal amount: 5 M\u20ac, 336 k\u20ac for MaMBIO. Period: 09\/2022 – 08\/2026
\nFor further details, please visit the project website at https:\/\/www.hypelignum.eu\/<\/a><\/h4>\n

NanoAntiCOVID: Use of antianemic drugs and contrast agents based on iron oxide nanoparticles as antiviral drugs against SARS-CoV-2 and influenza viruses (Ref. PDC2021-120759-I00)<\/span>:<\/strong>
\nFunding agency: MICINN (AEI, Proof-of-concept, 2021)
\nPrincipal investigator: Domingo Barber (CNB-CSIC)
\nTotal amount: 150 k\u20ac. Period: 2 years<\/h4>\n

Study of the synergy of the nanothermal and radiosensitizing effects in cells and tumours:<\/u>
\nFunding agency: MICINN (AEI, Generaci\u00f3n de Conocimiento 2021)
\nPrincipal investigator: Ana Espinosa
\nTotal amount: 97 k\u20ac. Period: 2022 \u2013 2025<\/h4>\n

MAG4Spinal: Smart magnetic bio-implants for neural regeneration: Application to spinal cord injury (Ref. PID2020-113480RB-I00)<\/span>:<\/strong>
\nFunding agency: MICINN (AEI, Retos de la Sociedad 2020)
\nPrincipal investigators: Sabino Veintemillas and M. Concepci\u00f3n Serrano
\nTotal amount: 217.8 k\u20ac. Period: 01\/09\/2021 – 31\/08\/2024<\/h4>\n

MAG4Spinal project aims to develop a novel therapy for spinal cord injury based on the use of new magnetic scaffolds of high magnetic response as bio-implants, in combination with motor rehabilitation, to drive functional neural repair. This novel regenerative rehabilitation approach based on 3D-bioprinted scaffolds containing immunoactive modulators is expected to be per se capable of unblocking inherent neural regeneration mechanisms and promoting neural plasticity routes.<\/p>\n

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NESTOR-H2020-MSCA-RISE (GA No.101007629)<\/span>:<\/strong>
\nPrincipal investigator: Gerardo Goya (Universidad de Zaragoza)<\/strong>
\nPrincipal investigator CSIC: M. Puerto Morales<\/strong>
\nTotal amount: 837 k\u20ac, CSIC 156.4 k\u20ac. Period: 2021 – 2025
\n<\/strong><\/h4>\n

NESTOR project aims to develop atomically-designed nanozymes based on versatile iron-oxide-based materials, to assess their true toxicological impact and to theoretically model the microscopic mechanisms of their enzymatic-like reactions (e.g.<\/em> catalase-like, peroxidase-like) and to achieve a product-oriented enzymatic activity with minimum toxicological impact, a highly relevant societal concern.<\/p>\n

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IMAGINE: Implementing MAgnetic targeting of nano-Guided ImmuNE cells<\/span>:<\/strong>
\nFunding agency: Fight Kids Cancer 2020 by European Science Fondation<\/strong>
\nPrincipal investigator: Antonio P\u00e9rez-Martinez (Hospital La Paz). Participants: Spain- France- Norway<\/strong>
\nTotal amount: 500 k\u20ac (CSIC 125 k\u20ac, PI Domingo Barber). Period: 03\/2021 – 12\/2024<\/strong>
\n\"\"<\/h4>\n

MARGO: MAxillofacial bone Regeneration by 3D-printed laser-activated Graphene Oxide scaffolds<\/span>:
\nFunding agency: FLAG\u2013ERA JTC 2019 – European Commission\/Ministerio de Ciencia, Innovaci\u00f3n y Universidades
\nCoordinator: Claudio Conti (Univ. Sapienza, Rome, Italy). Participants: Spain – Italy – Greece
\nTotal amount ICMM-CSIC: 150 k\u20ac (PI CSIC: Cefe L\u00f3pez). Period: 05\/2020 – 12\/2023<\/p>\n

Research on SARS-COV-2 and COVID19 disease, Proyectos intramurales CSIC especiales (Ref No. 202020E154)<\/span>:
\nPrincipal investigator: Dr. DOMINGO FRANCISCO BARBER CASTA\u00d1O (CNB-CSIC)
\nProject title: \u00abNanopart\u00edculas inmunosupresoras con tropismo a pulm\u00f3n para frenar la tormenta de citoquinas causante de la inmunopatolog\u00eda pulmonar y la replicaci\u00f3n viral\u00bb
\nTotal amount: 75 k\u20ac (12 k\u20ac ICMM-CSIC, PI CSIC: M. Puerto Morales). Period: 11\/05\/2021 – 10\/05\/2023<\/p>\n

HOTZYMES: Redesigning biocatalysis: Thermal-tuning of one-pot multienzymatic cascades by nanoactuation<\/a> (GA 829162)<\/span>:
\nFunding agency: European Commision, H2020 FET-OPEN-RIA
\nCoordinator: Valeria Grazu (ICMA-CSIC); PI ICMM-CSIC: M. Puerto Morales (WP1 leader)
\nTotal amount: 2,99 M\u20ac (ICMM-CSIC: 128 k\u20ac). Period: 2019-2022<\/p>\n

COMANCHE: Colloidal magnetic nanoparticles for catalysis, health and environment (Ref. MAT2017-88148-R)<\/span>:
\nFunding agency: MINECO (AEI, Retos de la Sociedad 2017)
\nPrincipal investigator: M. Puerto Morales
\nTotal amount: 181.5 k\u20ac. Period: 2018-2021<\/p>\n

SECURMAT: Separation and Extraction of Cesium, Uranium and other Radioactive metals by magnetic materials (Ref. I-LINK1229)<\/span>:
\nFunding agency: CSIC
\nParticipants: ICMM-CSIC and UNIVERSIT\u00c9 PARIS DIDEROT (France)
\nPrincipal investigators: M. Puerto Morales and Miryana Hemadi
\nTotal amount: ~20 k\u20ac. Period: 01\/2018 – 12\/2019<\/p>\n

ByAxon: Towards an active bypass for neural reconnection<\/a> (GA 737116)<\/span>:
\nFunding agency: European Commission, H2020 FET-OPEN-RIA
\nCoordinator: Rodolfo Miranda (IMDEA-Nanociencia). PI ICMM-CSIC: M. Concepci\u00f3n Serrano (WP3 leader)
\nTotal amount (CSIC+SESCAM): 453 k\u20ac. Period: 2017-2020. Participants: Spain – France – Italy – Germany<\/p>\n

In close collaboration with national and international research institutions of scientific excellence such as the IMDEA-Nanociencia (Spain, coordinator), the International School for Advanced Studies in Trieste (Italy), the Centre National de la Recherche Scientifique (France), the Servicio de Salud de Castilla-La Mancha (Spain) and the company mfd Diagnostics (Germany), this project focuses on the design and development of a novel prototype based on sensors and electrodes fabricated by last regeneration Nanotechnology techniques and able to reconnect neural circuitries through the injured spinal cord.<\/p>\n

ENTREMAT-NEU: Design and development of a bioactive 3D biomaterial made of graphene oxide and functionalized for the treatment of injured spinal cord (Ref. MAT2016-78857- R)<\/span>:
\nFunding agency: MINECO (AEI, Retos de la Sociedad)
\nPrincipal investigator: M. Concepci\u00f3n Serrano
\nTotal amount: 121 k\u20ac. Period: 2016-2020<\/p>\n

Following with the research topic consolidated with the project CP13\/00060 associated to the Miguel Servet I contract of Mar\u00eda Concepci\u00f3n Serrano at the Hospital Nacional de Parapl\u00e9jicos (funded by ISCIII-MINECO- FEDER from 2014 to 2016), this project focuses on the design and development of a bioactive 3D biomaterial based on reduced graphene oxide and able to efficiently promote neural repair responses in the injured spinal cord by means of a significant functional recovery.<\/p>\n

Magnetic nanoparticles for environment and health applications (Ref. PIE 201760E007)<\/u>:
\nFunding agency: CSIC
\nPrincipal investigator: M. Puerto Morales
\nTotal: 66 k\u20ac. Period: 01\/2017 – 12\/2019<\/p>\n

MAGO: Single-core and multi-core magnetic nanocrystals for biomedical applications<\/span>:
\nPrincipal investigator: Sabino Veintemillas Verdaguer
\nTotal Amount: 181 k\u20ac. Period: 2015-2017<\/p>\n

This project consists in a detailed and systematic study of the properties of iron oxide magnetic nanocrystals (for its low toxicity) with particle sizes greater than 15 nm (to neglect surface effects) and smaller than 30 nm (to avoid the multidomain formation) forming single and multi core nanostructures, in powder form and in colloidal dispersion. The relationship among the microstructure (crystal size, number of magnetic cores, coating thickness) nature of the magnetic material (magnetite-maghemite, ferrihydrite and core-shell hybrid inorganic  materials), magnetic properties and the applicability of these colloids in Biomedicine will be studied.<\/p>\n

NanoMag: Nanometrology Standardization Methods for Magnetic Nanoparticles<\/span>:
\nPrincipal Investigator CSIC: M. Puerto Morales
\nFinancing Agency: European Commission, FP7
\nTotal amount: 520 k\u20ac Period: 2013-2017<\/p>\n

The aim of the NanoMag project was to improve and redefine existing analyzing methods and in some cases, to develop new analyzing methods for magnetic nanostructures. Using improved manufacturing technologies we synthesized magnetic nanoparticles with specific properties that were analyzed with a multitude of characterization techniques (focusing on both structural as well as magnetic properties) and brought the experimental results together to obtain a self-consistent picture which described how structural and magnetic properties are interrelated. This extensive survey was used to define standard measurements and techniques necessary for defining a magnetic nanostructure and quality control.<\/p>\n

Tracking of magnetic nanoparticle biodistribution<\/span>:
\nFunding agency: AXA Research Fund Project<\/p>\n

The aim of this project was to characterise the biodistribution of magnetic nanoparticles for cancer treatment after intravenous systemic administration and their degradation over time. Outcomes from this project helped to identify the risk of exposure to new technologies, in particular to nanotechnology, which is one of the research priorities of the Biomedical Risk section from the Life Risks eligible research field of the AXA Research Fund. http:\/\/researchfund.axa.com\/project\/lucia-gutierrez-marruedo<\/a><\/p>\n

IronM@N: Multifunctional nanostructures based on iron oxide (Ref. MAT2011-23641)<\/span>:
\nFundign agency: MINECO, Spain
\nPrincipal investigator: M. Puerto Morales
\nTotal amount: 230 k\u20ac. Period: 2011-2015<\/p>\n

The aim of this project was to develop versatile preparation routes for a better control of the crystallochemical and structural factors that govern the properties of materials in which at least an iron oxide phase is a basic component. We were interested in applications (biomedical and water splitting) in which good crystallinity, good morphology control, good adsorption capabilities and sizes of the primary units within the nanoscale are required.<\/p>\n

MULTIFUN: Multifunctional Nanotechnology for selective detection and Treatment of cancer (Ref. C-NMP\/0878)<\/span>:
\nFunding agency: European Commission FP7-NMP-2010-LARGE-4
\nPrincipal investigator CSIC: M. Puerto Morales<\/p>\n

NANOBIOMAGNET: Fundamentos y aplicaciones de moleculas, nanopart\u00edculas y nanoestructuras (Ref. S2009\/MAT-1726)<\/span>:
\nFunding agency: Comunidad de Madrid, Consejer\u00eda de Educaci\u00f3n y Ciencia<\/p>\n

MULTIPLAB: Preparation of multifunctional nanoplatforms for bioimaging (Ref. MAT2008-01489\/NAN)<\/span>:
\nFunding agency: MINECO, Spain<\/p>\n

The main objective of this project was to obtain new multifunctional magnetic nanoplatforms based on Fe-Si-Bi by thermal decomposition and laser pyrolysis and to develop new colloidal processing routes such as coating with inorganic compounds or encapsulation into liposomes to optimize the performance of such materials as molecular probes for different medical imaging techniques than MPI.<\/p>\n

BONSAI: Bio-imaging with smart functional nanoparticles (Ref. LSHB-CT-2006-037639)<\/span>:<\/p>\n

The overall objective of this project was the development of novel multifunctional nanoparticles based on Si and Fe by laser pyrolysis technique with tailored optical and magnetic properties for visualizing complex cellular structures (in tissues and organs), receptors, tumor cells and masses by ultrasensitive bio-imaging techniques.<\/p>\n

NANOMAGNET: Magnetic nanostructures: Preparation, properties and biomedical and technological application (Ref. S-0505\/MAT\/0194)<\/span>:
\nFunding agency: Comunidad de Madrid, Consejer\u00eda de Educaci\u00f3n y Ciencia<\/p>\n

This project aimed to study the interaction mechanisms of magnetic nanoparticles and cells and the effect of particle nature, size and coating on them.<\/p>\n

MAGICO: Magnetic nanocomposites for biomedical applications (Ref. NAN2004-08805-C04-01)<\/span>:
\nFunding agency: MINECO<\/p>\n

The aim of this project was to develop state-of-the-art synthetic routes that could allow a rigorous microstructural control to obtain nanoparticulate magnetic materials with adequate composition and properties (magnetic, colloidal and chemical) to be used in the biotechnology field in both in vitro (chemical separation) and in vivo applications (magnetic resonance imaging and suppression of malignancy).<\/p>\n","protected":false},"excerpt":{"rendered":"

In the last 10 years, the permanent members of the MAMBIO Group have participated as coordinators\/WP leaders\/principal investigators in over 25 different research projects funded by the European Commission (8; e.g., Piezo4Spine, HyPELignum, MULTIFUN, NANOMAG and ByAxon), the Spanish Government (8; e.g., TED2021-130191B-C41, IRONM@N, MAGO, COMANCHE and MAG4SPINAL), the Comunidad de Madrid Regional Funding Programmes…
Leer m\u00e1s<\/a><\/p>\n","protected":false},"author":46,"featured_media":0,"parent":0,"menu_order":3,"comment_status":"closed","ping_status":"closed","template":"","meta":{"ngg_post_thumbnail":0,"footnotes":""},"class_list":["post-35","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/pages\/35","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/users\/46"}],"replies":[{"embeddable":true,"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/comments?post=35"}],"version-history":[{"count":90,"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/pages\/35\/revisions"}],"predecessor-version":[{"id":1876,"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/pages\/35\/revisions\/1876"}],"wp:attachment":[{"href":"https:\/\/wp.icmm.csic.es\/csc\/wp-json\/wp\/v2\/media?parent=35"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}